Best Supplements for Cold Sores

By Maya

Cold sores, also known as fever blisters, are small, painful lesions typically caused by the herpes simplex virus (HSV-1). They often appear around the lips or mouth and can be triggered by stress, illness, sun exposure, or a weakened immune system. For many, cold sores are not only uncomfortable but also emotionally distressing due to their visibility and recurrence.

While antiviral medications can help, natural supplements may offer a gentle, effective way to support the body’s defenses and reduce the frequency and severity of outbreaks.

Here are two evidence-based supplements that can be helpful for managing cold sores.

L-Lysine

L-Lysine is one of the most studied natural supplements for cold sores. This essential amino acid works by interfering with the replication of HSV-1 and helping to reduce the duration and intensity of outbreaks. It may also help prevent recurrence when taken regularly.

  • Mechanism of action: Inhibits the activity of arginine, an amino acid that HSV-1 uses to replicate
  • Dosage or usage tip: Take 1,000 mg daily for prevention, and up to 3,000 mg daily during outbreaks
  • Buy link placeholder: [Buy L-Lysine here]

Zinc

Zinc is a vital mineral for immune function and skin healing. Topical zinc formulations have shown promise in speeding the healing of cold sores, and oral zinc supplements may help bolster the immune response to reduce outbreak frequency.

  • Mechanism of action: Supports immune function and antiviral defense
  • Dosage or usage tip: Take 15–30 mg daily with food to avoid stomach upset
  • Buy link placeholder: [Buy Zinc here]

In Summary

Cold sores are a common yet frustrating condition for many people. Incorporating natural supplements like L-Lysine and Zinc into your routine may help reduce how often they appear and how long they last. Both support immune health and target the virus’s ability to replicate.

As always, talk with a healthcare provider before starting any new supplement—especially if you’re managing a chronic condition or taking medications.

This article is for informational purposes only and does not constitute medical advice.